Desirox 500 mg Tablet

Desirox 500 mg Tablet – Product Description

Brand Name: Desirox
Active Ingredient: Deferasirox
Formulation: Tablet
Manufacturer: Cipla Ltd.
Packging:available  of 30 tablet per bottle.

Description:

Desirox 500 mg Tablet contains Deferasirox, a medication used to manage iron overload in patients who require regular blood transfusions, such as those with thalassemia, sickle cell disease, or myelodysplastic syndromes. It is also used in patients with ineffective erythropoiesis to treat iron overload in the absence of transfusions.

Deferasirox is an iron chelator that works by binding to excess iron in the body, allowing it to be excreted primarily through urine. This helps prevent the damaging effects of iron accumulation in vital organs such as the liver, heart, and endocrine glands.

Indications:

Desirox 500 mg Tablet is used for the treatment of:

• Chronic Iron Overload Due to Blood Transfusions: Common in patients with thalassemia major, sickle cell disease, and other conditions that require frequent blood transfusions.

• Non-Transfusional Iron Overload: For patients with iron overload caused by ineffective erythropoiesis (such as in certain types of anemia) or those without frequent transfusions.

  Dosage and Administration:

• Chronic Iron Overload Due to Blood Transfusions:

  • Starting Dose: Typically, the starting dose is 14 mg/kg of body weight per day, taken once daily. This can be adjusted based on iron levels and clinical response.

• Non-Transfusional Iron Overload:

  • The dose generally starts at 10 mg/kg per day and may be adjusted according to the patient’s serum ferritin levels.

• Administration:
  Desirox should be taken on an empty stomach, at least 30 minutes before a meal. The tablet should be swallowed whole with a glass of water.

• Adjustments: Dosage may need to be adjusted based on iron levels, kidney and liver function tests, and clinical response. Regular monitoring is necessary.

Side Effects:

Common side effects may include:

• Gastrointestinal issues: Nausea, vomiting, diarrhea, or abdominal pain.

• Skin rash or itching.

• Fatigue or weakness.

• Elevated liver enzymes: Monitor for signs of liver damage (e.g., jaundice, dark urine).

Serious side effects include:

• Liver Damage: Signs of liver dysfunction like yellowing of the skin/eyes (jaundice), dark urine, or abdominal swelling.

• Kidney Damage: Changes in urination or swelling in the legs or feet.

• Auditory or visual disturbances: Rarely, it may cause hearing loss or vision problems.

Immediate medical attention is required if serious side effects occur.

Precautions:

• Liver or Kidney Issues: Desirox should be used with caution in individuals with liver or kidney diseases. Regular monitoring of liver and kidney function is necessary during treatment.

• Pregnancy and Breastfeeding: Desirox should only be used in pregnancy if absolutely necessary, and the use of Deferasirox during breastfeeding is not recommended.

• Allergic Reactions: If there is a known allergy to deferasirox or any of its components, the medication should be avoided.

Drug Interactions:

Desirox 500 mg Tablet may interact with the following:

• Cyclosporine, tacrolimus, or other immunosuppressants may affect kidney function when used together with deferasirox.

• Antacids containing aluminum, calcium, or magnesium can decrease the absorption of deferasirox.

• Rifampicin and other liver enzyme inducers can reduce the effectiveness of deferasirox.

It is important to inform your healthcare provider of all medications you’re taking to prevent possible interactions.

Storage Instructions:

• Store the tablets at room temperature (15°C to 30°C), away from direct light, moisture, and heat.

• Keep out of the reach of children.

• Do not use the medication after its expiration date.

Disclaimer:

This product description provides general information and is not a substitute for professional medical advice. Always follow the instructions of your healthcare provider and consult them regarding any concerns or side effects. Regular monitoring during treatment is necessary to ensure safety and effectiveness.